Ok, both cables will work, nice, because I find it much easier finding high quality USB 2 cables, not sure why.
Had an interesting experience recently when connecting an external headphone amp (Topping A90) to my Zen Dac using RCA cables and running the Zen Dac in fixed mode.
I experienced interference/noise using USB 3 port but it is dead quiet when using the USB 2 port (on my computer). Connecting the Zen Dac using the iPower X 5V power supply. If not running it with the iPower X (thus USB powered) I could actually hear some interference from the USB 2 connection too (the iPower X helps for sure).
Another forum user in the Topping A90 thread explained the RCA "noise" is a ground loop noise (from Topping A90) - and ground noise brought in from USB cable through the Zen Dac. Best/easiest way solving this is using balanced cable between amp and dac.
It's dead quiet right now connecting to USB 2 but I am thinking of a higher quality USB cable anyway. Also I will switch to a balanced cable (4.4mm -> dual 3 pin XLR) between the Zen Dac and the Topping A90 within 2-3 week.