Think i've had the HD-650 now for 2 years. Hard to believe since I disliked a few older pairs. It gets more use now than my modded Q701 because it's a little more comfortable and doesn't feel like it's on my head.
For music I slightly prefer the modded Q701, but for gaming/movies the HD-650 is usually on my head. I'd say it's now my most used headphone. For bedroom use I have it connected to an O2.
I still think my HD-650 sounds basically neutral. I don't hear any emphasis and it's really just smooth sounding with some slight treble roll-off. I got it to sound less like this with many different amps but I don't like this.
I think it sounds amazing with the Headroom Micro Stack (Astrodyne required for best results!). It's soundstage is capable of being very large/spacious and airy sounding with the proper recordings. With movies and with a lowly O2 it sounds home theater like at times. Some say the HD-650 has a closed in soundstage, but I totally disagree. Not on my amps at least. I also don't find it as forgiving as some say. Maybe a little with the brightest recordings.
I'm really sick of headphones and haven't purchased any new ones over $100 in probably a year. I keep trying to find an amp that sounds better to MY EARS under $500 but haven't been able to do it. I like the uncolored/more analytical sound I guess. I'm perfectly happy with what I have though. Headroom gear is very underrated (and discontinued).
So far now I think i'll stick with the HD-650/Q701 and my DJ100. I have a K400 but they're so bass light that it kind of ruins the experience of some music. They do sound perfect for female vocals and especially (some) acoustic music.
My DJ100 with M50 pads is very close in sound to my HD-650, but has more treble and slightly more sub-bass. Unfortunately it generally stinks with portable players. Due to it's pads it can probably sound very bad for some, even with M50 pads.
I know this may be off the general consensus, but i've found it very possible to dislike a specific headphone on the wrong amp (despite it having enough power to drive it). I had that experience with my first K702 and HD-650.
Right now the HD-650 is sounding so good that there is not one thing I want to improve on. Even the low-bass is good and similar to the modded Q701 (which increases low bass presence).
I still need to try the Bifrost. Pretty sure i'd love that (I'm a Modi fanboy). Think i'll skip the Lyr (probably wouldn't like it), but the Valhalla sounds more like something i'd like for the HD-650. Despite it having less power for a 38ohm headphone I bet it'd still sound good with the Q701.
If I ever get rich I'd love to try the HE-500, but probably won't be happening this year. Apparently my amp can handle that with ease, but probably might struggle with the HE-6. I'll never buy a $1000 headphone EVER, even if i'm a millionaire. To want to do that i'd have to listen to music more than 2 hours per day!