For the RE-0 only it would probably be smarter to get a player like the Clip+. The reason is that the iPod has a pretty non-linear frequency response, it rolls off the bass and scales up to the highs so it sounds bright. The RE-0 is already bright, so they won't go well together. An amp might solve this issue (if whatever is messing up the FR is before the amp of the iPod), but it's not the best solution. It's an overkill, like using a machine gun to kill a fly. However the Clip+ only outputs 489mV while the iPod is something like 1V, so you'd need to crank up the volume a bit on the Clip+. Also I doubt an amp is important to "bring out the full potential" of the RE-0 since it has 64ohm impedance. This kind of invalidates my previous point about the iPod making the RE-0 brighter (more impedance, less affected by weird FR), but the point remains that a Clip+ is cheaper than a portable amp.