I have the HD 660s and the HD 6XX (HD 650) and I have to say, I can BARELY tell the difference between the 660s and the 6XX. I tried flipping back and forth as fast as I can and I squinted to hear the difference and it's not like night and day where I could really tell which pair I was wearing. That being said, I'm sure they're different and it's just a matter of my brain forgetting what the sound was like while trying to switch pairs.
That being said, I struggled to hear the difference in imaging too. Like, I want to believe the 660s are better at imaging, but I just couldn't tell. Maybe my ears aren't trained well enough, or there's just enough unit variation that mine are similar to one another.
Also, looking at the graphs that Crinacle has on his site, the 660s looks drastically different than the 6XX in regards to bass extension and treble, but that's not what I'm hearing with mine. You'd think based on the graphs that the 660s is VERY dark sounding and the 6XX has quite a bit more bass, but I'm not hearing that.
I'm not an expert on any of this. I'm just a lover of music and the sound quality of these are off the charts in my opinion.