Just Got some 250 ohm pros to replace my SR325is (prefer coilied cable and the flexibility of the 250 ohm, 600's didn't sound dramatically better to me, etc.) Thinking of getting a magni/modi to match with them soon, as my desktop rig. (have a Fiio E18 that actually drives them pretty well)
I have to say, these cans do something really special for me. I tend to like brighter cans, and clarity is big for me so these deliver in spades. Transparency on these cans is very high for me; great details, soundstage and imaging. comfort is obviously quite high. Bass is great. I could see them being a little analytical for people who like warm sounds. This and the Sennheiser 598 are kind of like two different but equally affordable flavors of the a similar can IMO.
Classical is just stellar, and I actually find the vocals quite enjoyable. The separation is one of the only headphones good enough at this price to make really thick mixes like Janelle Monae and Melody Gardot sound superbly clear. Games are some of the best in class. Exceptionally approachably headphones unless you are super treble-sensitive, etc.
In terms of attainable and convenient headphones these (besides maybe the HE-400i) are pretty much end-game for me until I have a lot more disposable income! Might write a more in-depth (and maybe compare them with other cans) Good to be part of the Beyer club!
Happy Listening